(R)-3,N-dimethyl-N-[1-methyl-3-(4-methyl-piperidin-1-yl) propyl]benzenesulfonamide: the first selective 5-HT7 receptor antagonist

J Med Chem. 1998 Feb 26;41(5):655-7. doi: 10.1021/jm970519e.

Authors

I T Forbes¹, S Dabbs, D M Duckworth, A J Jennings, F D King, P J Lovell, A M Brown, L Collin, J J Hagan, D N Middlemiss, G J Riley, D R Thomas, N Upton

Affiliation

¹ Department of Medicinal Chemistry, SmithKline Beecham Pharmaceuticals, Harlow, Essex, England.

PMID: 9513592
DOI: 10.1021/jm970519e

No abstract available

MeSH terms

Adenylyl Cyclases / metabolism
Binding, Competitive
Cell Line
Gene Expression
Humans
Magnetic Resonance Spectroscopy
Molecular Structure
Piperidines / chemical synthesis*
Piperidines / pharmacology
Receptors, Serotonin / drug effects*
Receptors, Serotonin / genetics
Receptors, Serotonin / physiology
Serotonin Antagonists / chemical synthesis*
Serotonin Antagonists / pharmacology
Stereoisomerism
Structure-Activity Relationship
Sulfonamides / chemical synthesis*
Sulfonamides / pharmacology

Substances

3,N-dimethyl-N-(1-methyl-3-(4-methylpiperidin-1-yl)propyl)benzenesulfonamide
Piperidines
Receptors, Serotonin
Serotonin Antagonists
Sulfonamides
serotonin 7 receptor
Adenylyl Cyclases